The key of antibody-mediated immunological therapy is strong specificity of target antigen, low immunogenicity, high affinity of antibody and so on.
而抗体介导的免疫治疗的关键是靶抗原的特异性强，抗体的免疫原性低及亲和力高等。
Conclusion With the increase of the immunization times, the affinity of antibody come to mature and the proportion of dominant linear epitopes of BSA became higher.
结论抗体抗原亲和力随免疫次数的增加趋向饱和，BSA的线性表位为优势表位，随免疫次数的增加比重逐渐增强。
Because this method was to simulate the process of antibody maturation in vivo, the obtained antibodies was not only fully humanized but also with relatively high affinity.
该方法体外模拟了抗体亲和力成熟的过程，使得到的抗体不但可以完全的人源化，而且可以具有较高的亲和力。
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